Attribute Details
Active Ingredient Sildenafil Citrate
Dosage Forms 25mg, 50mg, 100mg
Administration Route Oral
Onset of Action 30-60 minutes
Duration of Effect 4-5 hours
Storage Conditions Below 30°C, away from moisture
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Pharmacokinetics

The pharmacokinetic profile of Silagra 100mg is well-documented. This medication, primarily used in managing erectile dysfunction, falls within the phosphodiesterase type 5 (PDE5) inhibitors. Upon oral ingestion, it undergoes rapid absorption. Its absorption is moderate and bioavailability reaches about 40%. It achieves peak plasma concentrations within an hour under fasting conditions. Metabolism primarily occurs in the liver via the cytochrome P450 enzyme CYP3A4, with a minor contribution from CYP2C9. The half-life extends to around 3 to 5 hours, with excretion occurring predominantly in feces and to a lesser extent in urine.

Silagra’s binding affinity to plasma proteins is approximately 96%, which implies limited free drug availability. Such a binding characteristic affects its distribution volume, averaging around 105 liters. These factors jointly facilitate the drug’s effective functioning within the stipulated dosage range. Its pharmacokinetics underline the importance of adhering to prescribed dosing regimens to optimize therapeutic outcomes and mitigate potential side effects.

How should Silagra be used?

Silagra 50mg should be taken as needed, ideally 30 to 60 minutes before planned sexual activity. The standard initial dose stands at 50 mg, subject to adjustment based on efficacy and tolerability. Patients may escalate the dose to 100 mg or reduce it to 25 mg. Administration should not exceed once daily.

Consumption with a high-fat meal may delay its onset of action, although this does not significantly impact overall efficacy. For optimal results, adherence to dosing recommendations is crucial. Individuals should not self-medicate or alter their dosage without consulting healthcare professionals. Concomitant use with nitrates or nitric oxide donors is contraindicated due to the risk of severe hypotension.

FDA-Approved Indications

The FDA endorses Silagra 100mg for managing erectile dysfunction (ED). This indication highlights its utility in facilitating the attainment and maintenance of an erection suitable for sexual intercourse. The approval underscores its well-established safety and efficacy profile when utilized according to prescribing guidelines.

Clinical studies demonstrate significant improvement in erectile function following Silagra administration. Its action mechanism involves enhancing the effect of nitric oxide by inhibiting PDE5, which regulates blood flow to the penis during sexual arousal. Beyond ED, Silagra’s role in treating pulmonary arterial hypertension underlines its versatility, although such use may involve different dosing protocols and brand formulations.

Silagra Interactions

Drug interactions constitute a crucial consideration when using Silagra 50mg. Co-administration with certain agents can amplify adverse effects or diminish therapeutic efficacy. Nitrate-containing medications or recreational substances like amyl nitrite should be avoided due to hypotensive risks.

Silagra also interacts with alpha-blockers, antihypertensives, and ritonavir, necessitating careful dose adjustments and monitoring. CYP3A4 inhibitors, such as ketoconazole or erythromycin, may increase sildenafil plasma levels, warranting caution. Patients should inform their healthcare provider of all concurrent medications, supplements, and herbal products to prevent undesirable interactions.

Toxicity

Silagra toxicity is rare but possible, particularly with overdose or misuse. Symptoms may include severe hypotension, syncope, or priapism. Priapism, a prolonged and painful erection, requires immediate medical attention to prevent tissue damage.

In overdose scenarios, supportive measures are vital, alongside symptomatic treatment. Dialysis does not significantly enhance clearance due to high protein binding. Patients with hepatic or renal impairment warrant dose adjustments to mitigate potential toxicity risks. Adverse events should be promptly reported to healthcare professionals for timely intervention.

Where to buy Silagra online

Purchasing Silagra online demands caution and verification. Reliable sources offer the assurance of authentic and safe products. Reputable online pharmacies ensure regulatory compliance, quality control, and provide access to comprehensive product information.

Consumers should prioritize licensed platforms with positive reviews and transparent practices. Online consultations may offer the added advantage of personalized advice and dosing guidance. Vigilance against counterfeit products is crucial, as these pose significant health risks. Potential buyers must exercise due diligence in selecting trusted vendors to secure legitimate and effective treatment.

Parameter Details
Bioavailability ~40%
Protein Binding 96%
Metabolism Hepatic (CYP3A4)